Cupric ion release and cytotoxicity for Yuangong Cu-IUDs and the release behavior of indomethacin for medicated 220 Cu-IUD

These years Yuangong copper-bearing intrauterine devices （Cu-IUDs） have been used because of less side effects in use. The corrosion of copper is essential to the success of contraception, and the release behavior of indomethacin from medicated Cu-IUD is related to its therapeutic effect. In this study, analytical methods were established to investigate the release behavior of cupric ion of three kinds of Yuangong Cu-IUDs and indomethacin of medicated Yuangong 220 Cu-IUD. Cu-IUDs were incubated in simulated uterine solution （SUS）. The concentrations of cupric ion and indomethacin were analyzed by flame atomic absorption spectrometer （FAAS） for 60 days and UV/vis -3310 spectrophotometer for 60 days, respectively. The morphology of copper after corrosion was characterized by SEM. In addition, we detected cytotoxicity by MTT of L929 mouse fibroblasts cells caused by extracts of the three Yuangong Cu-IUDs. The release behavior of cupric ion for three kinds of Yuangong Cu-IUDs was biphasic, which consisted of the initial burst release and then slow and constant release. In vitro release experiment confirmed a biphasic release of indomethacin from Yuangong 220. The copper wire of Yuangong Cu-IUDs showed uneven corrosion. The RGR value of Yuangong 365 Cu-IUD was smaller than that of medicated Yuangong 220 Cu-IUD and RGR value of medicated Yuangong 220 Cu-IUD was smaller than that of Yuangong 300 Cu-IUD. The cupric ion release and indomethacin release showed biphasic. Indomethacin increased the cupric ion release rate and might diminish the adverse effects caused by burst release of cupric ion. The toxicity grade of these three Yuangong Cu-IUDs was 4. We should canvass the adverse events of Cu-lUDs based on practical experiments, and try our best to reduce the toxicity of Cu-lUDs.     

钢纤维混凝土桥面铺装层的细观应力破坏分析

基于复合材料力学和线弹性断裂力学,简化了桥面铺装层及桥面板体系的力学模型,建立了修正的剪滞控制方程组.将模型裂缝区及远场的应力、位移条件合理转换为所建立计算模式的求解边界条件,进而得到了桥面铺装层和桥面板各子层的位移分布函数.运用能量法则,考虑温度效应对桥面铺装层的影响,得到了桥面铺装层破坏应力的解析解.运用该计算模式对某桥桥面铺装层的破坏进行了仿真分析,证实了该方法的适用性.     

柴油机燃用生物柴油燃烧与排放

研究了柴油机燃用0号柴油和生物柴油的燃烧放热规律．通过对燃烧特征参数的计算分析，发现生物柴油的燃烧始点有所提前，滞燃期缩短；燃烧初期放热尖峰出现时刻对应的曲轴转角有所提前，瞬时放热率峰值下降；燃烧持续期延长．同时还比较了柴油机燃用生物柴油和0号柴油的经济性和排放特性，发现燃油消耗率增加12％，而各种排放污染物除NOx略有上升外，CO、HC和颗粒物PM均显著下降．     

浙江天童常见植物幼树器官的氮磷养分特征

对浙江天童39种常见植物幼树的养分分配研究表明：常绿阔叶幼树中叶养分含量为：N1.059 %-2.896 %，P 0.069 %-0.126 %，落叶阔叶幼树叶的养分含量为：N1.868 %-3.254 %，P 0.092 %-0.186%，针叶树马尾松幼树叶的养分含量为：N1.874 %，P 0.078 %，植物不同器官营养含量不同，叶中N和P含量明显高于其它器官，茎和根中N和P的含量较低.通过ANOVA分析可知，不同生活型植物叶中N和P含量差异显著，落叶阔叶树种养分含量高于常绿阔叶树种，而枝、茎和根中N和P含量差异不显著；常绿阔叶树种不同生活型植物N和P含量存在一定差异，常绿阔叶乔木树种N和P含量高于常绿阔叶灌木树种.利用PCA和聚类分析发现，该地区不同演替阶段优势种养分含量具有相似性，根据不同器官养分含量特征，演替系列上的常见种的养分利用策略可分为3种类型，即“快生长策略”、“养分保留策略”及其它类型；植物不同器官中N和P含量均存在相关性，但相关程度在不同器官中表现不同，其相关系数大小为:叶>茎>枝>根；不同器官吸收N和P存在正相关关系.     

细胞活性测定方法研究进展

细胞活性测定是体外筛选抗肿瘤药物和临床肿瘤药敏试验的重要方法之一;细胞活性的测定方法有MTT法、SRB法3、H-TdR掺入法、LDH法等,根据不同细胞系及其测定原理,它们有各自的优缺点及最适测定条件;概述了近年来细胞活性测定的几种常见方法、原理及应用特点。     

不同土壤营养面积对大豆冠层结构的影响

应用CI-110植物冠层分析仪,对不同生育时期不同营养面积的大豆群体冠层指标参数叶面积指数(LAI)、平均叶倾角(MLA)、散射光透过系数(TD)、直射光透过系数(TR)和叶分布进行测定。经过分析,不同营养面积所形成的冠层的指标参数是不同的,随着单株营养面积的减少,LAI逐渐增大;平均叶倾角先增大后减少;散射辐射和直射辐射逐渐降低,但是散射辐射始终大于直射辐射;叶片分布密度增大。单株营养面积大,所形成的冠层会给大豆一个宽松的生长环境,有利于产量因素的形成;单株营养面积小,所形成的冠层郁蔽,限制产量因素的形成。图2,表3,参15。     

Effect of Starch Sources on the Release Rates of Herbicides Encapsulated

The effects of starch sources on the behaviors of starch matrices and on the rates of herbicides released from the matrices were studied for slow release. The starches considered include native corn starch, wheat starch, potato starch and cassava starch. The matrices were prepared through encapsulating 2,4-dichlorophenoxyacetic or 2,4,5 trichlorophenoxyacetic acids as model herbicides with hot-gelatinized starch pastes. The encapsulation was evaluated in terms of herbicide content, swellability, encapsulation efficiency, and release rate. The results show that starch sources play an important role on the matrix behaviors and on release rates. The rate of 2,4-D released follows the order： wheat starch 〈 potaot starch 〈 corn starch 〈 cassava starch. And for the rate of 2,4,5-T, this order is nearly the same only with an exception that the late two kinds of starch are similar. It is also demonstrated that herbicides with different water solubility show different release rates, no matter what type of starch is used as the matrices.     

布置方式对胶合板装饰材料火灾行为的影响

选择胶合板作为研究对象，在ISO9705标准的全尺寸燃烧间内对其进行全尺寸火灾实验模拟，实验中胶合板以不同的方式布置在房间内：一种是仅布置在墙面上；一种是布置在墙面和顶棚上．实验测量了热释放速率、装饰材料表面温度等参数，通过对数据的分析，发现材料的点燃温度随着位置变化，范围在300～400℃之间；顶棚胶合板材料的存在会大大加速表面火蔓延，加强室内火灾的发展过程，促进轰燃的发生．     

蟹类的营养需求研究及其配合饲料研制

概述了中华绒螯蟹（Eriocheir sinensis）、青蟹（Sclla sp）和三疣梭子蟹（Portunus trituberculatu）等几种主要养殖蟹类的营养需求研究及其配合饲料研制的进展．主要包括蟹类的蛋白质、氨基酸、脂类、脂肪酸、磷脂、胆固醇、碳水化合物、维生隶、矿物质等营养需求研究及其配合饲料研制成果．最后。对今后开展蟹类营养需求研究以及系列配合饲料研制提出了若干建议．